Granzyme K (GZMK) Mouse Monoclonal Antibody [Clone ID: GM24C3]

Specifications

Product Data
Clone Name	GM24C3
Applications	ELISA, FC
Recommend Dilution	Flow Cytometry: 1.2 µg/106 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	GM24C3 was generated by genetic immunisation of BALB/c mice with an immunisation vector containing the Granzyme K cDNA
Specificity	This antibody recognizes Granzyme K (GZMK).
Formulation	PBS, pH 7.2 without preservatives State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	granzyme K
Database Link	Entrez Gene 3003 Human UniProt ID P49863
Background	Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
Synonyms	Granzyme-3, NK-tryptase-2, Fragmentin-3, TRYP2, NK-Tryp-2
Note	Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
Reference Data

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