CD66c/e Mouse Monoclonal Antibody [Clone ID: MUS]

CAT#: DM1203

CD66c/e mouse monoclonal antibody, clone MUS, Purified



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CNY 5,660.00


货期*
5周

规格
    • 100 ug

Cited in 1 publication.

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Specifications

Product Data
Clone Name MUS
Applications ELISA, FC, IF, IHC, WB
Recommend Dilution Flow Cytometry: 1.2 µg/106 cells.
ELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200.
Western blot: 4 µg/ml.
Immunohistochemistry: 1-2 µg/106 cells (on Cryosections).
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen MUS was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors (3).
Specificity This antibody reacts to CD66c/e.
Formulation Phosphate buffered saline, pH 7.2
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Background CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM6 expression is strongly upregulated already during early stages of adenocarcinoma formation (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1).
Synonyms CEACAM5, Carcinoembryonic antigen, CEA, Meconium Antigen 100, Normal Cross-reacting Antigen, CEACAM6, NCA
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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