IL16 Mouse Monoclonal Antibody [Clone ID: 398]

Specifications

Product Data
Clone Name	398
Applications	ELISA, WB
Recommend Dilution	ELISA: This antibody can be used as a capture antibody in sandwich ELISA applications for human IL-16 detection in combination with a monoclonal tracer/detection antibody. Suggested Capture Coating Dose: 0.3 µg/well. Substrate: TMB. If the above suggested conditions are followed, approximately 20pg/mL of IL-16 in serum/plasma or 15 pg/mL of IL-16 in cell medium/urine can be detected with an assay range of 0-1000 pg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant Human IL-16
Specificity	Reactive with natural and recombinant Human IL-16. This monoclonal antibody exhibits no detectable cross-reacting with Human Albumin Serum, Bovine Albumin Serum and other Human cytokines or growth factors tested such as IL-1beta, IL-8, IL-7 MCAF, TGF-beta1, EGF, bFGF, GM-CSF, M-CSF, TNF-alpha.
Formulation	0.01M PBS, pH 7.2 State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water is recommended and to adjust the final concentration to 1.0 mg/ml
Concentration	1.0 mg/ml (after reconstitution)
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	interleukin 16
Database Link	Entrez Gene 3603 Human UniProt ID Q14005
Background	IL16 is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils.
Synonyms	IL-16, LCF
Reference Data

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