DC SIGN (CD209) (Extracell. Dom.) Mouse Monoclonal Antibody [Clone ID: 118A8.05]

CAT#: DDX0200B-100

DC SIGN (CD209) (Extracell. Dom.) mouse monoclonal antibody, clone 118A8.05



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CNY 5,775.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Clone Name 118A8.05
Applications WB
Recommend Dilution WB
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen human (GMCSF + TNF) DC subset
Specificity human (epitope in extracellular domain)
Formulation Label: Biotin
State: 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol
Concentration lot specific
Conjugation Biotin
Storage Condition -20°C. KEEP CONTENTS STERILE: no preservative.
Coupled antibodies: glycerol protects from freezing.
Gene Name CD209 molecule
Background We have generated an antibody recognizing an antigen which has a tissular distribution and a size (western blot) identical to DC-SIGN. This antibody does not recognize DC-SIGN 1 expressed in HeLa cells. DCSIGN (“DC Specific, ICAM-3 Grabbing, Nonintegrin”) / CD209 is a type II membrane protein with an external mannose-binding C-type lectin domain, DC-SIGN is expressed by immature and mature dendritic cells (DC). In the skin, DC-SIGN+ DC are exclusively located in the dermis. DC-SIGN binds to ICAM-3 on resting T cells, establishing DC-T cell contact and adaptive immunity. DC-SIGN is a high affinity receptor for HIV gp120, allowing HIV capture and transmission to CD4+ T cells. In addition to HIV, DC-SIGN is a receptor for a number of other viral and cellular pathogens including Mycobacterium Tuberculosis, and is a major player in microbial evasion of the immune system.
(Geijtenbeek, T et al, Cell; 2000; 100: 587-597; van Kooyk Y et al, Nat. Rev. Immunol.; 2003; 3: 697-709)
Synonyms DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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