B7-1 (CD80) Mouse Monoclonal Antibody [Clone ID: MAB104]

Specifications

Product Data
Clone Name	MAB104
Applications	FC, FN
Recommend Dilution	FACS, cell culture. Studies of ligand/receptor interactions Cell adhesion molecule Signal transduction in T-B interaction Dendritic cells activation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Jijoye cells (human Burkitt’s lymphoma cell line).
Specificity	Human CD80.
Formulation	State: Purified State: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD80 molecule
Database Link	Entrez Gene 941 Human UniProt ID P33681
Background	The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation. (Vallé A. et al, 1990; Immunology, 69:531-535; Freeman GJ. et al, 1992; Blood, 79:489-494).
Synonyms	CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1
Reference Data

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