CD20 (MS4A1) Mouse Monoclonal Antibody [Clone ID: mAb 75]

Specifications

Product Data
Clone Name	mAb 75
Applications	FC, FN
Recommend Dilution	FACS, B cell growth induction.  Usage recommendation: *This monoclonal antibody may be used between 1-10 μg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	human tonsil germinal center B cells
Specificity	human CD20 on germinal center B cells and B cells of hairy cell leukaemia
Formulation	State: Purified State: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles.
Gene Name	membrane spanning 4-domains A1
Database Link	Entrez Gene 931 Human UniProt ID P11836
Background	monoclonal antibody mAb75 has been generated which binds to germinal center B cells but not to naïve / memory cells. It also binds to some Burkitt’s lymphomas and to all Hairy cell leukemias tested. The CD20 epitope recognized by mAb75 became detectable on naïve B cells in response to TNF- / and/or IL10. Interestingly IL4, IFNs and TGF are strong antagonists to mAb75 epitope induction. Ligation of mAb75 epitope was found to enhance B cell growth. (Meffre G. et al, unpublished data)
Synonyms	MS4A1, Leu-16, Bp35, B-cell marker
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.