beta 2 Microglobulin (B2M) Mouse Monoclonal Antibody [Clone ID: mAb4]

Specifications

Product Data
Clone Name	mAb4
Applications	ELISA, FC
Recommend Dilution	Surface Flow Cytometry, ELISA capture (runs with DDX0270 detecting antibody)
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	human tonsil B lymphocyte subsets
Specificity	human Beta-2-microglobulin
Formulation	State: Purified State: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	beta-2-microglobulin
Database Link	Entrez Gene 567 Human UniProt ID P61769
Background	The molecular complex of Class I antigen consists of a membrane-embedded, glycosylated heavy chain in tight but non-covalent association with β2-microglobulin. HLA class I molecules are heterodimers made of a 45 kDa α chain with three extracellular domains non-covalently associated with the invariant 12 kDa β2- microglobulin and are expressed on all nucleated cells. Monoclonal antibodies specific to human 2- microglobulin induce myeloma and leukaemia cell lines apoptosis in vitro. These same antibodies were also therapeutic in vivo, in mouse models of haematological tumour cells. (Yang J. et al, 2006; Canc. Cell., 10:295-305; Shi C. et al., 2009; Drug Discovery, 14:25-30)
Synonyms	B2M, Beta-2 microglobulin, Beta 2 microglobulin
Reference Data

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