FHIT Mouse Monoclonal Antibody [Clone ID: OTI2C2]

Specifications

Product Data
Clone Name	OTI2C2
Applications	IHC, WB
Recommend Dilution	WB 1:500~2000, IHC 1:500
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human FHIT (NP_002003) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	16.7 kDa
Gene Name	fragile histidine triad diadenosine triphosphatase
Database Link	NP_002003 Entrez Gene 14198 MouseEntrez Gene 60398 RatEntrez Gene 2272 Human UniProt ID P49789
Background	This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms	AP3Aase; FRA3B
Reference Data
Protein Pathways	Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

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