Factor XII (F12) Mouse Monoclonal Antibody [Clone ID: OTI5A6]
CAT#: CF807269
Carrier-free (BSA/glycerol-free) F12 mouse monoclonal antibody, clone OTI5A6 (formerly 5A6)
Formulation: Standard
View other "OTI5A6" antibodies (4)
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CNY 3,999.00
Specifications
Product Data | |
Clone Name | OTI5A6 |
Applications | WB |
Recommend Dilution | WB 1:500 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 73-372 of human F12(NP_000496) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | coagulation factor XII |
Database Link | |
Background | This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul |
Synonyms | HAE3; HAEX; HAF |
Reference Data | |
Protein Families | Druggable Genome, Protease, Secreted Protein |
Protein Pathways | Complement and coagulation cascades |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA807269 | F12 mouse monoclonal antibody, clone OTI5A6 (formerly 5A6) |
CNY 1,999.00 |
|
TA807269AM | F12 mouse monoclonal antibody, clone OTI5A6 (formerly 5A6), Biotinylated |
CNY 3,990.00 |
|
TA807269BM | F12 mouse monoclonal antibody, clone OTI5A6 (formerly 5A6), HRP conjugated |
CNY 3,990.00 |
|
TA807269S | F12 mouse monoclonal antibody, clone OTI5A6 (formerly 5A6) |
CNY 800.00 |
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