Tyrosine Hydroxylase (TH) Mouse Monoclonal Antibody [Clone ID: OTI1A12]

Specifications

Product Data
Clone Name	OTI1A12
Applications	IF, IHC, WB
Recommend Dilution	WB 1:4000, IF 1:100, IHC: 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TH(NP_000351) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55.4 kDa
Gene Name	tyrosine hydroxylase
Database Link	NP_000351 Entrez Gene 21823 MouseEntrez Gene 25085 RatEntrez Gene 7054 Human UniProt ID P07101
Background	The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Synonyms	DYT5b; DYT14; TYH
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Parkinson's disease, Tyrosine metabolism

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