alpha 1 Antitrypsin (SERPINA1) Mouse Monoclonal Antibody [Clone ID: OTI3C5]

Specifications

Product Data
Clone Name	OTI3C5
Applications	WB
Recommend Dilution	WB 1:1000~2000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 26-418 of human A1AT (NP_000286) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46.6 kDa
Gene Name	serpin family A member 1
Database Link	NP_000286 Entrez Gene 5265 Human UniProt ID P01009
Background	A1AT is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in A1AT gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Synonyms	A1A; A1AT; AAT; alpha1AT; PI; PI1; PRO2275
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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