Complement C3 (C3) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ID
Recommend Dilution	ELISA. Radial Immunodiffusion.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Purified C3d from pooled activated serum
Specificity	This antibody is specific for human C3d and gave a single arc in the alpha region when tested by IEP against aged human plasma (C3d) and a contiuous double arc in the alpha and beta regions when tested against fresh human plasma (C3 and C3d).
Formulation	Glycine buffered saline, containing 0.09 % Sodium Azide (NaN3), 0.09 % EACA, 0.01 % Benzamidine and 1 mM EDTA State: Ig Fraction State: Liquid Ig fraction
Purification	Ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20 °C. Ship at 2 - 8 °C. Avoid repeated freezing and thawing.
Gene Name	complement component 3
Database Link	Entrez Gene 718 Human UniProt ID P01024
Background	The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
Synonyms	CPAMD1, Complement component 3
Note	Identity was confirmed by double diffusion (ouchterlony) vs human plasma and a known anti-human C3d.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades, Systemic lupus erythematosus

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