Tenascin C (TNC) Mouse Monoclonal Antibody [Clone ID: T2H5]

Specifications

Product Data
Clone Name	T2H5
Applications	IHC, IP, WB
Recommend Dilution	Immunohistochemistry (paraffin sections): Immunohistochemical detection of tenascin is valuable for studies of tissue differentiation and tumour growth. The antibody T2H5 is excellent for staining of paraffin-embedded tissue sections. Heat-mediated antigen retrieval in citrate buffer. Western blotting: Recommended dilution: 1-2 μg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Protein preparation from a homogenate of a Human mammary tumour specimen.
Specificity	The antibody recognizes Tenascin, a large hexameric extracellular matrix glycoprotein.
Formulation	Phosphate buffered saline (PBS), pH~7.4 State: Purified State: Liquid purified Ig fraction from Hybridoma Culture Supernatant (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	tenascin C
Database Link	Entrez Gene 3371 Human UniProt ID P24821
Background	Tenascin is a high molecular ECM glycoprotein (MW app. 210-300 kDa), which contains hexamere repeat-rich single chains. It contains EGF-, Fibronectin III- and Fibronectin-similar structures. During organogenesis it is exprimed temporarily by many organs. During adulthood it reappears only in regeneration, wound healing and in stroma of various tumours. It probably has an anti-adhesive function, which plays a role during tumour speading. Tenascin is found in the central and peripheral nerve system, in smooth muscle, tendon and hyper-proliferative skin.
Synonyms	Tenascin-C, TN-C, Hexabrachion, Cytotactin, Neuronectin, GMEM
Reference Data

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