Integrin beta 1 (ITGB1) (beta-1D Isoform) Mouse Monoclonal Antibody [Clone ID: 2B1]

Specifications

Product Data
Clone Name	2B1
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/100-1/1000 Immunocytochemistry. Flow Cytometry. Immunohistochemistry on Frozen Tissues: 1/25 -1/200 with ABC as detection reagent.
Reactivity	Canine, Human, Mouse, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	A synthetic peptide corresponding to the C-terminal 24 amino acids of integrin b1D including an appending N-terminal cysteine coupled to keyhole limpet hemocyanin.
Specificity	2B1 recognizes specifically the cytoplasmic domain of integrin subunit b1D present in cardiac and skeletal muscle.
Formulation	PBS with 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin subunit beta 1
Database Link	Entrez Gene 3688 Human UniProt ID P05556
Background	Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. Their distribution pattern in adult tissues is mutually exclusive. bea1A is present in all tissues, except cardiac and skeletal muscle, which instead express the beta1D variant.
Synonyms	Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, ITGB1, FNRB, MDF2, MSK12
Reference Data

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