K Cadherin (CDH6) Mouse Monoclonal Antibody [Clone ID: 2B6]

Specifications

Product Data
Clone Name	2B6
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/25-1/250. Immunocytochemistry. Immunohistochemistry on Frozen Sections: Use a PBS buffer containing 0.1 mM CaCl2 and 0.1 mM MgCl2. Immunohistochemistry on Paraffin Sections. Recommended Dilutions: 1/25-1/250 for immunohistochemistry with ABC as detection reagent.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Affinity purified extracellular domain of Human Cadherin-6-GST fusion protein
Specificity	Clone 2B6 recognizes the extracellular domain of Cadherin-6.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cadherin 6
Database Link	Entrez Gene 1004 Human UniProt ID P55285
Background	Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
Synonyms	CDH6, Kidney cadherin, Cadherin K, K-Cadherin
Reference Data

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