Lamin A/C Mouse Monoclonal Antibody [Clone ID: 131C3]

Specifications

Product Data
Clone Name	131C3
Applications	FC, IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/100-1/1000. Flow Cytometry: 1/100-1/200. Immunocytochemistry. Immunohistochemistry on Frozen Sections: 1/100-1/200 with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent.
Reactivity	Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Rat liver Lamins.
Specificity	131C3 reacts with an epitope located between residues 319-566 in Lamin A and C. Immunoblotting of 131C3 recognizes Nuclear Lamins A and C in Human Fibroblasts.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	lamin A/C
Database Link	Entrez Gene 4000 Human UniProt ID P02545
Background	Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Synonyms	LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker
Reference Data

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