OATP2 (SLCO1B1) Mouse Monoclonal Antibody [Clone ID: mESL]

CAT#: BM5542

OATP2 (SLCO1B1) mouse monoclonal antibody, clone mESL, Supernatant



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CNY 4,280.00


货期*
5周

规格
    • 5 ml

Cited in 1 publication.

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Specifications

Product Data
Clone Name mESL
Applications IF, IP, WB
Recommend Dilution Immunoprecipitation.
Immunofluorescence Microscopy (Ready-to-use).
Incubation Time: 1 h at RT).
Western blotting: for optimal detection of the glycosylated antigen sample boiling before SDS-PAGE is not recommended; alternatively, samples should be kept at 37°C for 30 min (cf. Cui et al.).
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Synthetic C-terminus (21 aa) of Human organic anion transporter SLC21A6 coupled to KLH
Specificity The antibody reacts with OATP2/OATP1B1, Human organic anion transporter SLC21A6 (90 kD).
It recognizes SCL21A6 transfected HEK293 cells, negative with HepG2 and PLC (cultured cell lines tested so far).
Using Immunofluorescence Microscopy mESL stains the sinusoidal (basolateral) membranes in frozen sections of human liver, hepatocellular carcinoma and the human cell line HEK293 transfected with SLC21A6.
In Western blot analyses the monoclonal antibody mESL reacts selectively with the 90 kD protein (after SDS-PAGE) present in the basolateral membrane fractions of human liver. According to a recent new nomenclature this hepatocytespecific protein is identical to OATP1B1 (see Ref. 2) also known as OATP-C.
Formulation State: Supernatant
State: Liquid Culture Supernatant containing 0.09% Sodium Azide
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
Gene Name solute carrier organic anion transporter family member 1B1
Background The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATPC, and LST1.
Synonyms LST1, LST-1, OATP-2, OATPC, OATP-C, SLC21A6
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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