Desmoglein 2 (DSG2) Mouse Monoclonal Antibody [Clone ID: G129]
CAT#: BM5106
Desmoglein 2 (DSG2) mouse monoclonal antibody, clone G129, Supernatant
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CNY 4,340.00
货期*
5周
规格
Cited in 2 publications. |
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Specifications
Product Data | |
Clone Name | G129 |
Applications | ELISA, IHC, WB |
Recommend Dilution | ELISA. Western Blot. Immunohistochemistry on Frozen Sections: Ready-to-use (1 h at RT). Preincubation with 0.05-0.2% Triton X-100, for 5-10 min, depending on tissue type, is recommended. Immunohistochemistry on Paraffin Sections: Ready-to-use (overnight at 2-8°C). Enhanced when using the microwave method. Recommended as Positive Control: CaCo-2, HaCaT. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant peptide (220 aa of 2nd and 3rd extracellular repeat domain). |
Specificity | This antibody recognizes Desmoglein 2 present in all epithelia and in tumors derived therefrom as well as in heart muscle and dendritic reticulum cells of lymphatic follicles. In basal epithelial cells Desmoglein 2 expression is generally very low. Reactivities on Cultured Cell Lines: Many, including CaCo-2, HaCaT, MCF-7. Negative Species: Mouse, Rat. |
Formulation | State: Supernatant State: Liquid Cell Culture Supernatant Preservative: 0.09% Sodium Azide |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | desmoglein 2 |
Database Link | |
Background | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. |
Synonyms | DSG2, CDHF5,HDGC |
Note | Desmoglein 2 (1069 aa; calculated mol. wt. 116,760) |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion
,null,
Frontiers in Immunology
,PubMed ID 31178865
[DSG2]
|
Interleukin-10 Enhances the Intestinal Epithelial Barrier in the Presence of Corticosteroids through p38 MAPK Activity in Caco-2 Monolayers: A Possible Mechanism for Steroid Responsiveness in Ulcerative Colitis
,LorC)n V, CabrC) E, Ojanguren I, DomC(nech E, Pedrosa E, GarcC-a-Jaraquemada A, MaC1osa M, ManyC) J,
PLoS ONE
,PubMed ID 26090671
[DSG2]
|
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