K Cadherin (CDH6) Mouse Monoclonal Antibody [Clone ID: 2B6]

Specifications

Product Data
Clone Name	2B6
Applications	IHC
Recommend Dilution	Immunohistochemistry on frozen sections: paraformaldehyde fixed; with 0.2% Triton X-100 in PBS; Ready to use; 1 h at room temperature / overnight at 2-8°C.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	GST fusion protein of part of the extracellular domain of cadherin 6 (K-Cadherin).
Specificity	This antibody reacts to Cadherin 6.
Formulation	State: Supernatant State: Liquid Culture supernatant contains 0.1% sodium azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cadherin 6
Database Link	Entrez Gene 1004 Human UniProt ID P55285
Background	The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin-5, -6, -8, -11, and -12. During embryogenesis differential expression of cadherins can drive morphogenesis by stimulating cell aggregation, defining boundaries between groups of cells and promoting cell migration. Cadherin-6 seems to be required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium.
Synonyms	CDH6, Kidney cadherin, Cadherin K, K-Cadherin
Reference Data

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