CDK4 Mouse Monoclonal Antibody [Clone ID: DCS-35]
CAT#: BM5020
CDK4 mouse monoclonal antibody, clone DCS-35, Purified
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CNY 3,750.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | DCS-35 |
Applications | IP, WB |
Recommend Dilution | Western Blot. Immunoprecipitation: 1/3-1/10. Incubation Time: 1-4h at RT or overnight at 2-8°C. |
Reactivity | Human, Mouse, Porcine, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant full-length cdk4 polypeptide |
Specificity | This antibody reacts specifically with cdk4 protein present predominantly in G1 phase of cell cycle. It does not cross-react with cyclins. Especially suitable for Immunoprecipitation, mab DCS-35 precipitates the cdk4/cyclin complex (epitope localization: aa 1-20). Cellular Localization: Nuclear, Cytoplasmic. Mol. Wt. of Antigen: 34kDa |
Formulation | PBS, pH 7.4 State: Purified State: Lyophilized purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.09% Sodium Azide |
Reconstitution Method | Restore in 1 ml distilled water |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Gene Name | cyclin-dependent kinase 4 |
Database Link | |
Background | Cdk4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. Cdk4 is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1/S phase, which is controlled by the regulatory subunits D type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). The mutations in this gene as well as its related proteins including D type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Two alternatively spliced variants, and multiple polyadenylation sites of this gene have been reported. |
Synonyms | PSK-J3 |
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