Histone H1 Mouse Monoclonal Antibody [Clone ID: AE-4]
CAT#: BM465S
Histone H1 mouse monoclonal antibody, clone AE-4, Purified
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CNY 4,724.00
货期*
5周
规格
Cited in 7 publications. |
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Specifications
Product Data | |
Clone Name | AE-4 |
Applications | ELISA, IF, IHC, IP, WB |
Recommend Dilution | ELISA. Western blotting. Immunoprecipitation. Immunofluorescence. Immunhistology on Frozen and Paraffin Sections: Acetone or PFA fixation is recommended for Frozen sections. Positive Control Tissue: Tonsil. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A BALB/c mouse was immunized with Human leukemia biopsy cells. The isolated splenocytes were fused with mouse myeloma cells. |
Specificity | AE-4 recognizes Histone H1 in the nuclei of animal and plant cells. It produces a speckled nuclear staining pattern in normal and malignant cells. Tonsil is the recommended positive control tissue. |
Formulation | PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Background | The histone proteins serve as a structural scaffold for the organisation of nuclear DNA into chromatin. In eucariotic cells there are 4 core histone proteins, H2A, H2B, H3 and H4 that asseble to form an octamer round which the DNA is wrapped in a sequence dependant manner. The resulting complex is known as a nucleosome and is the basic subunit of chromatin. Histone H1 acts as a linker and binds to each nucleosome, and by self affinity, links these nucleosomes together resulting in the 30 nm chromatin fiber. |
Synonyms | H1 Histone Family, H1F4, H1F5, Histone H1a, Histone H1b |
Reference Data |
Citations (7)
The use of this Antibodies has been cited in the following citations: |
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Induction of immune responses by a novel recombinant fusion protein of enterovirus A71 in BALB/c mice.
,null,
Molecular immunology
,PubMed ID 30465931
|
Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection
,Sakamoto K, Geisel RE, Kim MJ, Wyatt BT, Sellers LB, Smiley ST, Cooper AM, Russell DG, Rhoades ER,
Infect. Immun.
,PubMed ID 20028811
|
Secretory overproduction of a raw starch-degrading glucoamylase in Penicillium oxalicum using strong promoter and signal peptide.
,null,
Applied microbiology and biotechnology
,PubMed ID 30155751
|
NADPH Oxidase Promotes Neutrophil Extracellular Trap Formation in Pulmonary Aspergillosis
,null,
Infection and Immunity
,PubMed ID 24549323
|
Vibrio cholerae Evades Neutrophil Extracellular Traps by the Activity of Two Extracellular Nucleases
,null,
PLoS Pathogens
,PubMed ID 24039581
|
Histone H1 functions as a stimulatory factor in backup pathways of NHEJ
,null,
Nucleic Acids Research
,PubMed ID 18250087
|
Expression of granule-associated proteins in neutrophils from patients with severe congenital neutropenia
,Andersson M, Karlsson J, Carlsson G, P|tsep K,
Blood
,PubMed ID 17881643
|
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