SIRT1 pSer47 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:500~1:1000.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence around phosphorylation site of serine 47(E-R-S(p)-P-G) derived from Human SirT1 (KLH-conjugated)
Specificity	The antibody detects endogenous level of SirT1 only when phosphorylated at serine 47.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography using epitope-specific peptide
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	110 kDa
Gene Name	sirtuin 1
Database Link	Entrez Gene 23411 Human UniProt ID Q96EB6
Background	NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively.
Synonyms	SIRT-1, SIR2-like protein 1, SIR2L1, sirtuin type 1, sirtuin 1, sirtuin-1, SIR2alpha
Reference Data

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