RUNX1 pSer435 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:500~1:1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide sequence around phosphorylation site of Serine 435( S-N-S(p)-P-T) derived from Human AML1 (KLH-conjugated)
Specificity	The antibody detects endogenous levels of AML1 only when phosphorylated at serine 435.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography using epitope-specific peptide
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	53 kDa
Gene Name	runt related transcription factor 1
Database Link	Entrez Gene 861 Human UniProt ID Q01196
Background	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.
Synonyms	Runt-related transcription factor, 1, AML1, AML-1, AMLCR1, Acute myeloid leukemia 1 protein, AML1-EVI-1, EVI-1, CBFA2, CBF-alpha-2, PEA2-alpha B, PEBP2-alpha B, PEBP2A2
Reference Data

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