beta Arrestin 1 (ARRB1) pSer412 Rabbit Polyclonal Antibody
CAT#: AP55695PU-N
beta Arrestin 1 (ARRB1) pSer412 rabbit polyclonal antibody, Aff - Purified
Size: 50 ul
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CNY 2,250.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | Western blot: 1:500~1:1000. Immunohistochemistry on paraffin sections: 1:50~1:100. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around phosphorylation site of Serine 412 (T-G-S(p)-P-Q) derived from Human Arrestin 1 (KLH-conjugated) |
Specificity | The antibody detects endogenous levels of Arrestin-1 only when phosphorylated at serine 412. |
Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Affinity chromatography using epitope-specific peptide |
Conjugation | Unconjugated |
Storage Condition | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Predicted Protein Size | 50 kDa |
Gene Name | arrestin beta 1 |
Database Link | |
Background | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. |
Synonyms | ARR1, Beta-arrestin-1 |
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