TGF beta 2 (TGFB2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/500-1/5000. Immunohistochemistry: 1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from N-terminal domain of Human TGFB2
Specificity	Reacts with Human 48 kDa TGFB2 protein.
Formulation	0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified powder Preservative: None
Reconstitution Method	Restore in distilled water.
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer Avoid repeated freezing and thawing.
Gene Name	transforming growth factor beta 2
Database Link	Entrez Gene 7042 Human UniProt ID P61812
Background	Transforming growth factor beta's (TGF beta's) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFalpha. It is now realized that TGF beta's mediate many cell-cell interactions that occur during embryonic development. Three TGF beta's have been identified in mammals. TGFB1, TGFB2 and TGFB3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFB3 protein has approximately 80% identity to the mature region of both TGFB1 and TGFB2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.
Synonyms	Transforming growth factor beta-2, G-TSF, Polyergin, Cetermin
Reference Data

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