Sprouty 4 (SPRY4) Rabbit Polyclonal Antibody

CAT#: AP55302PU-N

Sprouty 4 (SPRY4) rabbit polyclonal antibody, Purified



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CNY 6,886.00


货期*
8周

规格
    • 100 ug

Cited in 1 publication.

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution

ELISA.
Western Blot: 1/500-1/2000.
Immunohistochemistry: 1/100-1/500.

Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from N-terminal region of Sprouty homolog 4 (Spry-4)
Specificity Reacts with Human 32 kDa Spry-4 protein.
Cross reacts with Mouse, Bovine and Chicken.
Formulation 0.1M Tris, 0.1M Glycine and 2% Sucrose
State: Purified
State: Lyophilized purified antibody
Preservative: None
Reconstitution Method Restore in distilled water.
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Condition

Prior to reconstitution store the antibody at -20°C.
Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name sprouty RTK signaling antagonist 4
Background Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.
Synonyms Spry-4, Sprouty 4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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