Sprouty 4 (SPRY4) Rabbit Polyclonal Antibody
CAT#: AP55302PU-N
Sprouty 4 (SPRY4) rabbit polyclonal antibody, Purified
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CNY 6,886.00
货期*
8周
规格
Cited in 1 publication. |
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Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommend Dilution | ELISA. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from N-terminal region of Sprouty homolog 4 (Spry-4) |
Specificity | Reacts with Human 32 kDa Spry-4 protein. Cross reacts with Mouse, Bovine and Chicken. |
Formulation | 0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified antibody Preservative: None |
Reconstitution Method | Restore in distilled water. |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Prior to reconstitution store the antibody at -20°C. |
Gene Name | sprouty RTK signaling antagonist 4 |
Database Link | |
Background | Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine. |
Synonyms | Spry-4, Sprouty 4 |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis
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PLoS ONE
,PubMed ID 19424491
[SPRY4]
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