EGR2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/500-1/2000. Immunohistochemistry: 1/50-1/500.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from N-terminal domain of Mouse EGR-2 protein
Specificity	Reacts with Mouse 50 kDa EGR-2. Cross reacts with proteins from Rat, Human and other species due to sequence homology.
Formulation	State: Serum State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Store lyophilized antibody at -20°C Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	early growth response 2
Database Link	UniProt ID P11161
Background	Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92% identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause of Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.
Synonyms	Early growth response protein 2, EGR-2, AT591, KROX20, Krox 20
Reference Data

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