EGR2 Rabbit Polyclonal Antibody

CAT#: AP54904SU-N

EGR2 rabbit polyclonal antibody, Serum



Need it in bulk or conjugated?
Get a free quote

CNY 6,600.00


货期*
8周

规格
    • 200 ul

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution ELISA.
Western Blot: 1/500-1/2000.
Immunohistochemistry: 1/50-1/500.
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from N-terminal domain of Mouse EGR-2 protein
Specificity Reacts with Mouse 50 kDa EGR-2.
Cross reacts with proteins from Rat, Human and other species due to sequence homology.
Formulation State: Serum
State: Lyophilized powder
Preservative: None
Reconstitution Method Restore in distilled water.
Conjugation Unconjugated
Storage Condition

Store lyophilized antibody at -20°C
Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name early growth response 2
Background Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92% identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause of Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.
Synonyms Early growth response protein 2, EGR-2, AT591, KROX20, Krox 20
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...