CDC25C pSer198 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot. Immunohistochemistry.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptides derived from internal domain of Human CDC25C protein.
Specificity	This antibody reacts with 53 kDa CDC25C with a phosphorylated Serine 198. Cross-reacts with the isoforms 2; 4 and 5 of Human CDC25C protein.
Formulation	State: Serum State: Lyophilized serum Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cell division cycle 25C
Database Link	Entrez Gene 995 Human UniProt ID P30307
Background	Cyclin-dependent kinases can be activated by CDC25, which removes inhibitory phosphates from tyrosine and threonine residues. At least three CDC25 genes (CDC25A, CDC25B, and CDC25C) have been identified in humans. Whereas CDC25A and CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A and in both G1-S-phase and G2 for CDC25B, CDC25C is predominantly expressed in G2. Cdc25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It has been highly conserved during evolution and it plays a key role in the regulation of cell division. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Cdc25C is mainly expressed in G2 phase. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
Synonyms	CDC25
Reference Data

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