TAZ (WWTR1) (C-term) Rabbit Polyclonal Antibody
CAT#: AP54578PU-N
TAZ (WWTR1) (C-term) rabbit polyclonal antibody, Aff - Purified
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | ELISA: 1:1;000. Western blot: 1:100~500. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 369-398 amino acids from the C-terminal region of human WWTR1. |
Specificity | This antibody detects WWTR1 / TAZ (C-term). |
Formulation | PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein A column followed by peptide affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Gene Name | WW domain containing transcription regulator 1 |
Database Link | |
Background | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
Synonyms | DKFZp586I1419; FLJ27004; FLJ45718; TAZ |
Note | Molecular Weight: 44101 Da |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
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