SMURF1 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100 - 1/500.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 351-381 amino acids from the Central region of human SMURF1
Specificity	This antibody reacts to SMURF1.
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	86114 Da
Gene Name	SMAD specific E3 ubiquitin protein ligase 1
Database Link	Entrez Gene 75788 MouseEntrez Gene 57154 Human UniProt ID Q9HCE7
Background	This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.
Synonyms	SMURF 1, SMURF-1, KIAA1625
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis

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