RASA1 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 965-993 amino acids from the C-terminal region of Human RASA1 / RasGAP.
Specificity	This antibody recognizes Human RASA1 / RasGAP (C-term).
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	RAS p21 protein activator 1
Database Link	Entrez Gene 5921 Human UniProt ID P20936
Background	The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Synonyms	Ras GTPase-activating protein 1, GAP, Ras p21 protein activator, p120GAP, RASA, p120RASGAP
Note	Molecular Weight: 116403 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Axon guidance, MAPK signaling pathway

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