RAMP3 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the C-terminal region of human RAMP3
Specificity	This antibody recognizes Human and Mouse RAMP3 (C-term).
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	receptor (G protein-coupled) activity modifying protein 3
Database Link	Entrez Gene 56089 MouseEntrez Gene 10268 Human UniProt ID O60896
Background	The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
Synonyms	CRLR activity-modifying protein 3
Note	Molecular Weight: 16518 Da
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Vascular smooth muscle contraction

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