AMPK alpha 2 (PRKAA2) (Center)/(Thr172) Rabbit Polyclonal Antibody
CAT#: AP53442PU-N
AMPK alpha 2 (PRKAA2) (Center)/(Thr172) rabbit polyclonal antibody, Aff - Purified
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | FC, IHC, WB |
Recommend Dilution | Western Blot: 1/1000 (tested in K562 cell line lysates (35µg/lane). Immunohistochemistry on paraffin sections: 1/10 - 1/50. Flow Cytometry: 1/10 - 1/50. ELISA: 1/1000. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 145-173 amino acids from the Central region of human PRKAA2 (Thr172) |
Specificity | This antibody reacts to PRKAA2. |
Formulation | PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) sodium azide |
Concentration | lot specific |
Purification | Affinity chromatography on Protein A |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Predicted Protein Size | 62320 Da |
Gene Name | protein kinase AMP-activated catalytic subunit alpha 2 |
Database Link | |
Background | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
Synonyms | AMPK2, AMPK alpha-2 chain |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, mTOR signaling pathway, Regulation of autophagy |
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