Calcium independent Phospholipase A2 (PLA2G6) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, WB
Recommend Dilution	Flow cytometry: 1/10-1/50. Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin sections: 1/50-1/100. Western blot: 1/50-1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the central region (between 558-588aa) of human PLA2G6.
Specificity	This antibody recognizes PLA2G6.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	phospholipase A2 group VI
Database Link	Entrez Gene 8398 Human UniProt ID O60733
Background	The protein encoded by the PLA2G6 gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells.
Synonyms	IPLA2, Cal-PLA2, GVI PLA2, Group VI phospholipase A2, PARK14
Note	Molecular Weight: 89903 Da
Reference Data
Protein Pathways	alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

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