PDE4 (PDE4B) (Center) Rabbit Polyclonal Antibody
CAT#: AP53236PU-N
PDE4 (PDE4B) (Center) rabbit polyclonal antibody, Aff - Purified
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | FC, WB |
Recommend Dilution | ELISA: 1/1000. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 196-225 amino acids from the Central region of Human PDE4B |
Specificity | This antibody recognizes Human PDE4B (Center). |
Formulation | PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein A column, followed by peptide affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | phosphodiesterase 4B |
Database Link | |
Background | This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Synonyms | PDE4B, DPDE4, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, EC=3.1.4.17, PDE32 |
Note | Molecular Weight: 83343 Da |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Progesterone-mediated oocyte maturation, Purine metabolism |
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