TTF1 (NKX2-1) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	Flow cytometry: 1/10-1/50. Western blot: 1/100-1/500. Enzyme immunoassay: 1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 1-30aa) of human NKX2-1
Specificity	This antibody recognizes human TTF1 / NKX2A at N-term.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	NK2 homeobox 1
Database Link	Entrez Gene 7080 Human UniProt ID P43699
Background	The NKX2-1 gene encodes a protein initially identified as a thyroid-specific transcription factor (TTF). TTF1 binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	NKX2-1, Nkx-2.1, TITF1, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1
Note	Molecular Weight: 38596 Da
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

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