MAD3 (MXD3) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot:  1/100-1/500. Enzyme immunoassay:  1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 27-56aa) of human MAD3
Specificity	This antibody recognizes human MAD3 at N-term.
Formulation	PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	MAX dimerization protein 3
Database Link	Entrez Gene 83463 Human UniProt ID Q9BW11
Background	The MXD3 gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The Max-associated protein 3 / MAD3 forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.
Synonyms	MAD-3, MXD3,Max-interacting transcriptional repressor MAD3
Note	Molecular Weight: 23477 Da
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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