EVI1 (MECOM) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 80-109 amino acids from the Central region of human MDS1
Specificity	This antibody recognizes Human and Mouse MDS1 (Center).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	MDS1 and EVI1 complex locus
Database Link	Entrez Gene 14013 MouseEntrez Gene 2122 Human UniProt ID Q03112
Background	MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.
Synonyms	Myelodysplasia syndrome 1
Note	Molecular Weight: 18696 Da
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Chronic myeloid leukemia, MAPK signaling pathway, Pathways in cancer

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