Leucyl cystinyl aminopeptidase (LNPEP) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000 Western Blot: 1/100-1/500. Flow Cytometry: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of Human LNPEP.
Specificity	This antibody recognizes Human LNPEP (N-Term).
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	leucyl/cystinyl aminopeptidase
Database Link	Entrez Gene 4012 Human UniProt ID Q9UIQ6
Background	This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Synonyms	LNPEP, OTASE, Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, EC=3.4.11.3, Oxytocinase, Insulin-responsive aminopeptidase, IRAP, Placental leucine aminopeptidase, P-LAP
Note	Molecular Weight: 117349 Da
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein, Transmembrane
Protein Pathways	Renin-angiotensin system

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