IL10 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Flow Cytometry:  1/10-1/50. Immunohistochemistry on Paraffin Sections:  1/10-1/50. Western blotting: 1/1000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated corresponding to the center region (between aa 27-53) of Human IL10.
Specificity	This antibody detects Human IL10. Other species not tested.
Formulation	PBS with 0.09% (W/V) Sodium Azide. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Purified through a protein A column; followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 10
Database Link	Entrez Gene 3586 Human UniProt ID P22301
Background	Interleukin-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Synonyms	IL-10, CSIF, TGIF
Note	Molecular Weight: 20517 Da
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways	Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway

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