HSD11B2 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	This antibody is suitable for Western Blotting, Flow cytometry and Paraffin sections. The suggested dilution is: ELISA: 1:1;000 Western blotting: 1:100~500 Immunohistochemistry: 1:50~100 Flow cytometry: 1:10~50
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 284~314 amino acids from the Central region of human HSD11B2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. State: Aff - Purified State: Liquid
Concentration	lot specific
Purification	This antibody is purified through a protein A column; followed by peptide affinity purification.
Conjugation	Unconjugated
Storage Condition	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene Name	hydroxysteroid (11-beta) dehydrogenase 2
Database Link	Entrez Gene 3291 Human UniProt ID P80365
Background	There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Synonyms	11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2
Note	Molecular Weight: 44127 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.