ERCC8 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of Human ERCC8
Specificity	This antibody recognizes Human and Mouse ERCC8 (Center).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Database Link	Entrez Gene 71991 MouseEntrez Gene 1161 Human UniProt ID Q13216
Background	This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Synonyms	CKN1, CSA, ERCC-8
Note	Molecular Weight: 44055 Da
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Nucleotide excision repair, Ubiquitin mediated proteolysis

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