Cathepsin K (CTSK) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/1000 Immunohistochemistry on Paraffin Sections: 1/10-1/50. Flow Cytometry: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 96-126 amino acids from the Central region of Human Cathepsin K
Specificity	This antibody recognizes Human Cathepsin K.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) Precipitation
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	36966 Da
Gene Name	cathepsin K
Database Link	Entrez Gene 1513 Human UniProt ID P43235
Background	The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq].
Synonyms	Cathepsin O, Cathepsin X, Cathepsin O2, CTSK, CTSO, CTSO2
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Lysosome

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