BCL2A1 (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western blotting: 1/50 - 1/100. Immunohistochemistry on paraffin sections: 1/50 - 1/100. Flow cytometric: 1/10 - 1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 63~92 amino acids from the Center region of human BCL2A1
Specificity	This antibody reacts to Bcl-2-like 5.
Formulation	PBS containing 0.09% (W/V) sodium azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	BCL2 related protein A1
Database Link	Entrez Gene 597 Human UniProt ID Q16548
Background	Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Synonyms	BCL2A1, BCL2L5, BFL1, GRS, HBPA1, Bcl-2-like protein 5, Protein BFL-1
Note	Molecular Weight: 20132 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways

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