Acrosin (ACR) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western blotting: 1/50 - 1/100. Immunohistochemistry 1/50 - 1/100. Flow cytometric 1/10 - 1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 106~135 amino acids from the Center region of human ACR
Specificity	This antibody reacts to Acrosin.
Formulation	PBS containing 0.09% (W/V) sodium azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	acrosin
Database Link	Entrez Gene 49 Human UniProt ID P10323
Background	ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
Synonyms	acrosin; ACRS; preproacrosin; proacrosin
Note	Molecular Weight: 45847 Da
Reference Data
Protein Families	Druggable Genome, Protease

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