ARMET (MANF) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/200000.   Western Blot: 1/2000-1/6000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Human MANF produced using CHO-based.  Antigen is purified from cell culture supernatant.
Specificity	Recognizes Human MANF.  No cross-reactivity in MANF-knockout Mouse.
Formulation	Concentrated Ammonium Sulphate in PBS pH 7.4 State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store at 2-8°C. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use.
Gene Name	mesencephalic astrocyte derived neurotrophic factor
Database Link	Entrez Gene 7873 Human UniProt ID P55145
Background	MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
Synonyms	Arginine-rich protein, MANF
Reference Data

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