FPRL1 (FPR2) (2nd extracell. loop) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, WB
Recommend Dilution	Western blot: 1/4000-1/5000. Immunofluorescence: 1/400-1/500. Flow Cytometry: 1/100 using HL-60 as positive control.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A short peptide corresponding to the amino acids on the 2nd extracellular loop of Human FPRL1
Specificity	This antibody recognizes a 38kDa Human FPRL-1.
Formulation	0.01M PBS, pH 7.2 State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with double distilled Water to final Concentration of 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	formyl peptide receptor 2
Database Link	Entrez Gene 2358 Human UniProt ID P25090
Background	Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer’s disease.
Synonyms	N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R
Reference Data

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