Drebrin (DBN1) (1-326) Mouse Monoclonal Antibody [Clone ID: DBN-N-03]

Specifications

Product Data
Clone Name	DBN-N-03
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 Tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Specificity	This Monoclonal antibody DBN-N-03 recognizes Drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.
Formulation	PBS Label: PE State: Liquid purified IgG fraction Stabilizer: 0.2% (w/v) high-grade protease free BSA Preservative: 15 mM Sodium Azide Label: Phycoerythrin
Purification	Size-Exclusion Chromatography and adjusted for direct use. No reconstitution is necessary.
Conjugation	PE
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This products is photosensitive and should be protected from light.   Avoid repeated freezing and thawing.
Gene Name	drebrin 1
Database Link	Entrez Gene 1627 Human UniProt ID Q16643
Background	Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
Synonyms	DBN1, DBN-1, D0S117E, DKFZp434D064,drebrin 1
Reference Data

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