TSSC3 (PHLDA2) Goat Polyclonal Antibody

Specifications

Product Data
Applications	FC, PEP-ELISA, WB
Recommend Dilution	Peptide ELISA: 1/32000 (Detection limit). Western blot: Preliminary experiments gave no signal but low background in Jurkat and human placenta extracts at up to 1µg/ml. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Immunohistochemistry on Paraffin Sections: 3-6 μg/ml. In paraffin embedded Placenta shows staining of the syncytiotrophoblasts.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from the C-terminus of Human PHLDA2 (NP_003302.1).
Specificity	This antibody recognizes PHLDA2 at C-term.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	pleckstrin homology like domain family A member 2
Database Link	Entrez Gene 7262 Human UniProt ID Q53GA4
Background	TSSC3 in encoded in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.
Synonyms	BWR1C, HLDA2, IPL
Reference Data

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