Paralemmin (PALM) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/5000. Immunohistochemistry: 1/100-1/2000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from internal part of Human PALM protein.
Specificity	This antibody reacts with Paralemmin-1
Formulation	Tris 0,1M, glycine 0,1M, sucrose 2% State: Purified State: Lyohilized purified IgG fraction Preservative: None
Reconstitution Method	Restore in distilled water.
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibody at 2-4°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	paralemmin
Database Link	Entrez Gene 5064 Human UniProt ID O75781
Background	Paralemmin, also called Paralemmin-1 or PALM, is a widely expressed peripheral membrane protein that is involved in cell structure and shape. A hydrophobic protein, Paralemmin is anchored to the cytoplasmic side of the cell membrane via di-palmitoylation and prenylation of its C-terminal cysteine cluster. Functioning at the synapse to regulate neuronal plasticity and plasma membrane dynamics, Paralemmin can bind to the dopamine receptor D3, thereby reducing D3 expression and subsequent adenylate cyclase activity. Overexpression of Paralemmin induces fibroblasts to extend long filopodia and to assume extreme cell shapes, suggesting involvement in the formation and stabilization of the plasma membrane. Two isoforms of Paralemmin exists due to alternative splicing events.
Synonyms	Paralemmin, KIAA0270
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.